Polymorphisms of the fimbria fim3 gene of Bordetella pertussis strains isolated in Canada.

نویسندگان

  • Raymond S W Tsang
  • Allan K H Lau
  • Michelle L Sill
  • Scott A Halperin
  • Paul Van Caeseele
  • Frances Jamieson
  • Irene E Martin
چکیده

The fim genes which code for the fimbria protective antigens present in both the inactivated whole-cell and acellular vaccines were analyzed in 86 Canadian Bordetella pertussis isolates. At least one of the novel mutations identified was found to involve a surface epitope that has been mapped by serum antibodies from infected or vaccinated subjects.

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عنوان ژورنال:
  • Journal of clinical microbiology

دوره 42 11  شماره 

صفحات  -

تاریخ انتشار 2004